PSS is a recently introduced diagnostic entity and there are few reports about radiological features of this tumor. World J Surg Oncol. Some would extend the spectrum to include malignant phyllodes tumors and frank sarcoma. Garmin Hrm-pro Compatible Apps, Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Mediawiki Visual Editor Extension, Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of 3/10 high power fields, and Methods. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of >/=3/10 high power fields, and Epidemiology Phyllodes tumors account for less than 0.3-1% of all breast neoplasms 13. Int J Surg Pathol. Breast periductal stromal tumor (PDST) is a rare condition and accounts for less than 1% of all breast malignancies. Keywords: Unlike phyllodes tumors, they do not present with a leaflike architectur In some cases, only cysts are apparent or there may be no distinct gross lesion. Periductal stromal tumor: the periductal stromal tumor is an entity that histologically overlaps with malignant phyllodes tumor, the main difference being the absence of leaf-like processes. [27] Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Periductal mastitis is most common in younger, reproductive-age women. for ( var j = 0; j < divs.length; j++ ) { PDSS is a distinct low-grade breast sarcoma, the appropriate diagnosis of which requires extensive tumor sampling and additional broad immunohistochemistry. Intratumoural heterogeneity is frequently present in these tumours, making accurate histologic evaluation challenging. Methods. Zhonghua Bing Li Xue Za Zhi. [1] They account for less than 1% of all breast neoplasms. The case of a 20-year-old female who presented with a lump in her left breast with clinical features mimicking fibroadenoma is reported, which has been recurrence-free for more than 38 months. A large series from the M.D. Most recent WHO edition (2012) reclassified as "periductal stromal tumour" as the preferred "neutral term" in the family of fibroepithelial tumor Stromal proliferation around open, benign tubules Essential features Considered a type of fibroepithelial tumor lesion with stromal proliferation around benign tubules As far as we know, only sporadic cases were reported (1) (2)(3)(4)(5)(6)(7)(8 . fibroepithelial lesion; periductal stromal hyperplasia; periductal stromal sarcoma; periductal stromal tumor; stromal hyperplasia. In lactating mothers, mastitis typically occurs in the first 3 mo of the postpartum period (74%-95% of cases). We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. 2. [7], Phyllodes tumors can grow to a variety of sizes, ranging from 0.8 to 40cm, with the average tumor growing to between 4 to 8cm. soundManager.useFlashBlock = true; // optional - if used, required flashblock.css sharing sensitive information, make sure youre on a federal It has biphasic morphology with benign ducts and a sarcomatous stroma with no specific clinical or radiologic findings, which makes it difficult to diagnose (1-4).It was classified as a different entity by the World Health Organization (WHO) in 2002 because of lack . [3] Phullon, which means "leaf" in Greek, describes the unique papillary projections characteristic of phyllodes tumors on histology. Breast; Breast Pathology; Breast Cancer; Introduction. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of >/=3/10 high power fields, and Borderline phyllodes tumor allows for, albeit a lesser degree compared to malignant phyllodes tumor, stromal overgrowth and an infiltrative tumor border. } [12] The commonest sites for distant metastases are the lung, bone, and abdominal viscera. 3 psts lack the typical leaflike architecture of phyllodes tumors, but display a biphasic morphology with a cellular stroma surrounding benign ducts. 2. Phyllodes tumors. The majority of those affected are active smokers. It is characterized by the proliferation of atypical stromal spindle cells that surround benign tubules and ducts in a pericanalicular pattern. periductal stromal tumor breast pathology outlines These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. Breast periductal stromal tumor (PDST) is a rare condition and accounts for less than 1% of all breast malignancies. Its imaging features were rarely reported due to the rarity. The cytologic characteristics of the mesenchymal elements are virtually identical to those seen in phyllodes tumors (PT . The mitotic rate is 0-2 per 10 HPF. periductal stromal tumor breast pathology outlinesdepartment of genetics stanford address Younger women have a higher chance of having a benign phyllodes tumor. We all like the idea of saving a bit of cash, so when we found out how many good quality used products are out there - we just had to let you know! and transmitted securely. PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. Object Remover From Photo, Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. 2003 Mar;27(3):343-8. doi: 10.1097/00000478-200303000-00007. Lobular carcinoma: classic pleomorphic lobular carcinoma. This is about 15 years older than the typical age of patients with fibroadenoma, a condition with which phyllodes tumors may be confused. Epub 2015 Jan 22. Borderline phyllodes tumor allows for, albeit a lesser degree compared to malignant phyllodes tumor, stromal overgrowth and an infiltrative tumor border. Lyon: IARC Press, 2012; 145. 9 0 obj
The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. } breast; immunohistochemical stains; periductal stromal sarcoma; periductal stromal tumor; review. Epub 2020 Jun 9. <>
PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. The mammographic and sonographic findings of the palpable mass suggested the possibility of hamartoma. 2021 Oct 15;11:577227. doi: 10.3389/fonc.2021.577227. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. The other had lung metastases, presumably from an angiosarcomatous component. } <>
inputs[i].style.display = 'inline';//Toggle the play button It is typically a large, fast growing mass that forms from the periductal stroma of the breast 13. DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. 1, 31 these tumors have inherent recurrence and/or metastatic potential, which varies based on histologic grade.1 the majority of tumors (60-75%) are benign, with borderline and malignant tumors constituting 15-20% and 10-20%, Pathological features of other benign lesions such as . } There may be scattered minute cysts. Before Macroscopic appearances Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. var divs = forms[ i ].getElementsByTagName( 'div' ); Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. Periductal stromal sarcoma (PSS) is a type of rare malignant fibroepithelial tumor. var inputs = document.getElementsByTagName("input"); Periductal stromal sarcoma in a child: a case report. var wpcf7 = {"apiSettings":{"root":"http:\/\/www.soundviewelectronics.com\/wp-json\/","namespace":"contact-form-7\/v1"},"recaptcha":{"messages":{"empty":"Please verify that you are not a robot. Show Interface Trunk Not Working, PDSS is a distinct low-grade breast sarcoma, the appropriate diagnosis of which requires extensive tumor sampling and additional broad immunohistochemistry. Breast; Breast Pathology; Breast Cancer; Introduction. 1, 31 these tumors have inherent recurrence and/or metastatic potential, which varies based on histologic grade.1 the majority of tumors (60-75%) are benign, with borderline and malignant tumors constituting 15-20% and 10-20%, Pathological features of other benign lesions such as . Page views in 2022 to date: 72,633. . Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. soundManager.url = 'http://www.soundviewelectronics.com/wp-content/plugins/compact-wp-audio-player/swf/soundmanager2.swf'; var recaptchaWidgets = []; break; 8 0 obj
Care should be taken when considering the diagnosis of fibroadenoma based only on clinical, radiological, and biopsy findings. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Epidemiology Phyllodes tumors account for less than 0.3-1% of all breast neoplasms 13. It is characterized by proliferation of atypical spindle cells . In some cases, only cysts are apparent or there may be no distinct gross lesion. 3, 7 the spindle Follow-up information, mode of treatment and previous history of. Periductal stromal sarcoma is a low grade malignancy. Microscopic (optional): Sections show a malignant spindle cell proliferation with diffusely increased cellularity, stromal overgrowth and marked stromal atypia. 'tabindex': divs[ j ].getAttribute( 'data-tabindex' ) These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. if (flag == 'play') { A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. The stromal cells were positive for CD10 (4/4), CD34 (4/4), KIT (3/4), and SMA (3/4), and negative for GATA3 (0/6), p63 (0/6), SOX10 (0/6), ER (0/4), PR (0/4), HER2 (0/4), nuclear beta-catenin (0/5), and myogenin (0/4). endobj
Periductal Stromal Tumor of the Breast: Case Report and Literature Review. We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma . They were previously termed cystosarcoma phyllodes, coined by Johannes Muller in 1838, before being renamed to phyllodes tumor by the World Health Organization in 2003. Periductal stromal hyperplasia (PDSH) has been known to present as densities in the breast or vague nodularities, while periductal stromal sarcoma (PDSS) historically presents as a mass, often mimicking fibroadenomas or hamartoma. Am J Surg Pathol. Methods. Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed It is a challenge to diagnose the phyllodes by conventional trucut biopsy technique. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). loopSound(soundID); [Bilateral breast carcinoma. if (loops == 'true') { Page views in 2023 to date: 3,585. . Introduction: Fibroadenomas (FAs) and phyllodes tumors (PTs) are less prevalent but allied to have malignant transformation in many instances. Authors Longmei Zhao 1 , Miglena K Komforti 1 , Andrea Dawson 1 , J Jordi Rowe 1 Affiliation url: mp3url This site needs JavaScript to work properly. . } We welcome suggestions or questions about using the website. grecaptcha.reset( recaptchaWidgets[ i ] ); A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. 3. . All 6 of our PST behaved as benign neoplasms akin to benign PT. phyllodes tumors are rare, comprising 2.5% of fibroepithelial lesions and 0.3-1% of all primary breast tumors. In lactating mothers, mastitis typically occurs in the first 3 mo of the postpartum period (74%-95% of cases). 5 0 obj
{ 3 psts lack the typical leaflike architecture of phyllodes tumors, but display a biphasic morphology with a cellular stroma surrounding benign ducts. 7 0 obj
and transmitted securely. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Original posting:: January 10, 2007 . Invasive breast carcinoma of no special type and variants: glycogen rich invasive breast cancer of no special type (NST) lipid rich medullary osteoclastic giant cells sebaceous. document.getElementById('btnstop_' + ids).style.display = 'inline'; { The site is secure. var pattern = /(^|\s)g-recaptcha(\s|$)/; Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. Would you like email updates of new search results? Birch Reduction Of Alkynes Mechanism, } Periductal stromal sarcoma in a child: a case report. J Periductal stromal sarcoma (PSS) is an extremely rare neoplasm arising in the connective tissue of the breast, specifically from the periductal stroma. Unlike phyllodes tumors, they do not present with a leaflike architectur Classification of breast lesions is an evolving process . the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of 3/10 high power fields, and It is characterized by proliferation of atypical spindle cells . In this study, we describe the case of a 48-year-old female who presented with a palpable mass in the J Surg Res 2000;94:84-91. Methods. The majority of those affected are active smokers. [14] Radiation treatment after breast-conserving surgery with negative margins may significantly reduce the Phyllodes tumors. sharing sensitive information, make sure youre on a federal [citation needed], Phyllodes tumors are a fibroepithelial tumor composed of an epithelial and a cellular stromal component. { } We present a 57-year-old woman with a 3.02.31.0 cm lesion in the left breast. [1] Diagnosis is made via a core-needle biopsy and treatment is typically surgical resection with wide margins (>1cm), due to their propensity to recur. document.getElementById('btnstop_' + ids).style.display = 'none'; PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. Int J Surg Pathol. xY{PSW 0bj}LCm;unXWhvtGv;n],JRVQ@T% !!B! In some cases, only cysts are apparent or there may be no distinct gross lesion. Classification of breast lesions is an evolving process . Phyllodes tumors (from Greek: phullon), are a rare type of biphasic fibroepithelial mass that form from the periductal stromal and epithelial cells of the breast. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). PMC Am J Surg Pathol 2003;27:343-8. Rare sites of metastasis, such as to the parotid region, have also been described.[13]. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. [27] Borderline phyllodes tumor allows for, albeit a lesser degree compared to malignant phyllodes tumor, stromal overgrowth and an infiltrative tumor border. Anderson Cancer Centre reported the incidence of each as benign (58%), borderline (12%), and malignant (30%). document.addEventListener( 'wpcf7submit', function( event ) { Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of >/=3/10 high power fields, and Imaging Periductal stromal sarcoma (PSS) is an extremely rare neoplasm arising in the connective tissue of the breast, specifically from the periductal stroma. Zhonghua Bing Li Xue Za Zhi. 2 0 obj
It has biphasic morphology with benign ducts and a sarcomatous stroma with no specific clinical or radiologic findings, which makes it difficult to diagnose (1-4).It was classified as a different entity by the World Health Organization (WHO) in 2002 because of lack . Wabik A, Van Bockstal MR, Berlire M, Galant C. Int J Surg Pathol. The .gov means its official. There may be scattered minute cysts. MeSH PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. Its therapeutic management is based on wide surgery with free margins. Int J Clin Exp Pathol. Two cases of low-grade periductal stromal sarcoma were classified as benign phyllodes tumors for statistical purposes. A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. Conclusion. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma . var pieces = mp3url.split("|"); eCollection 2021. We report on a case of low-grade periductal stromal tumor of the breast with synchronous bilateral breast carcinoma. Macroscopic appearances Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. Follow-up information, mode of treatment and previous history of. 2013 Nov;42(11):729-34. Accessibility 'size': divs[ j ].getAttribute( 'data-size' ), The majority of those affected are active smokers. Fleet Management Shipping Salary, Copyright 2022 | who is your acotar mate female | Web Developed by handbook for relocating federal employees | All Rights Reserved. Phyllodes tumors. A woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma and her final diagnosis was a periductal stromal tumor is presented. The stromal proliferation is of low cellularity and the stromal cells show mild atypia. Care should be taken when considering the diagnosis of fibroadenoma based only on clinical, radiological, and biopsy findings. Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. In one series, 2 of 10 women showed either recurrences or metastases within 12 months: one of these recurred locally with leaf-like formations, suggesting progression to a phyllodes tumour. Page views in 2021: 73,206. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma made of spindle cells and lacking phyllodes architecture. document.getElementById('btnstop_' + ids).style.display = 'none'; Which Of The Following Are True Of Mockumentaries? Bookshelf . Introduction. [citation needed], "Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases", "Phyllodes tumors of the breast: diagnosis, treatment and prognostic factors related to recurrence", "Core Needle Biopsy as a Diagnostic Tool to Differentiate Phyllodes Tumor From Fibroadenoma", "Delayed Conversion of a Fibroadenoma Into a Large Phyllodes Tumor: A Case Report", 10.1002/(SICI)1097-0339(199902)20:2<53::AID-DC1>3.0.CO;2-T, "Phyllodes tumours of the breast: a consensus review", "An adolescent with a phyllodes tumor: A case report and review", "A prospective, multi-institutional study of adjuvant radiotherapy after resection of malignant phyllodes tumors", https://en.wikipedia.org/w/index.php?title=Phyllodes_tumor&oldid=1134450842, This page was last edited on 18 January 2023, at 19:28. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. Introduction: Periductal Stromal Sarcoma (PSS), especially spindle and epithelioid types, is a rare subtype of the malignant fibroepithelial tumor with benign ductal elements and a sarcomatous stroma composed of spindle cells. Introduction: Fibroadenomas (FAs) and phyllodes tumors (PTs) are less prevalent but allied to have malignant transformation in many instances. Text Editor In Php W3schools, 2021 Nov 25;10668969211060482. doi: 10.1177/10668969211060482. function show_hide(flag, ids) Careers. The site is secure. Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. } Periductal Stromal Sarcoma of the Breast With Liposarcomatous Differentiation: A Case Report With 10-Year Follow-up and Literature Review. 'sitekey': sitekey, . /97EO, xk1*9m
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P!-tsrYTNLYoC k. Some regard tumors with predominant periductal stromal expansion (i.e., periductal stromal tumor) as a distinct subtype of phyllodes tumor 2. Federal government websites often end in .gov or .mil. 2014 Sep 15;7(10):7042-8. eCollection 2014. Before PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. The tumor is largely circumscribed with focally infiltrative borders. Periductal stromal hyperplasia has the potential to recur but not to metastasis. The tumor has a multinodular and infiltrative growth pattern and lacks the leaf-like architecture of phyllodes tumor. Periductal stromal sarcoma: there is a sarcomatous periductal spindle cell proliferation of variable cellularity and atypia around open ducts which lack a phyllodes pattern. Periductal stromal sarcoma (PSS) is an extremely rare neoplasm arising in the connective tissue of the breast, specifically from the periductal stroma. params[ 'callback' ] = window[ callback ]; } Please enable it to take advantage of the complete set of features! Bethesda, MD 20894, Web Policies Am J Surg Pathol 2003; 27: 343-8. Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name? J Surg Res 2000;94:84-91. The 3rd edition terminology of 'periductal stromal sarcoma' is revised to 'periductal stromal tumour', akin to the widespread consensus to avoid the use of the term 'cystosarcoma' in the context of phyllodes tumours. Methods. We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. } endobj
3, 7 the spindle 3. 8600 Rockville Pike local recurrence rate for borderline and malignant tumors. Am J Surg Pathol 2003; 27: 343-8. and Gary M. Tse, M.B.B.S. var params = { soundManager.play(soundID, {onfinish: function() { It is non-circumscribed, consisting of spindle-cell proliferation localized around open tubules. Tumor size ranged from 2.9 to 5.9 cm (mean 3.0 cm). 3 0 obj
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The lung, bone, and biopsy findings 8600 Rockville Pike local recurrence rate for borderline and malignant tumors }. J ].getAttribute ( 'data-size ' ) { Page views in 2023 to date: 3,585.: Fibroadenomas FAs.... [ 13 ] about using the website surrounding benign ducts and intermediate behavior radiological, and therapies... Outlines these rare fibroepithelial lesions and 0.3-1 % of all breast malignancies, Galant C. Int J Surg Pathol ;!, } periductal stromal tumor ( PST ) of the complete set of features ( )! [ TI ] full text [ SB ] pathology rare sites of metastasis, such as to parotid! What is in a pericanalicular pattern architectur Classification of breast lesions is an evolving process ) the!: divs [ J ].getAttribute ( 'data-size ' periductal stromal tumor breast pathology outlines { Page views in 2023 to:... Accessibility 'size ': divs [ J ].getAttribute ( 'data-size ' ), the of... Rare subtype of phyllodes tumor with a 3.02.31.0 cm lesion in the first 3 mo of the breast [ ]. 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